ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

  1. 112 医学系研究科・医学部
  2. 50 疾患生命工学センター
  3. 1125010 学術雑誌論文
  1. 0 資料タイプ別
  2. 10 学術雑誌論文
  3. 014 自然科学

Treatment of neurological disorders by introducing mRNA in vivo using polyplex nanomicelles

http://hdl.handle.net/2261/56528
http://hdl.handle.net/2261/56528
1c7ebb38-0c3d-4ccc-abf7-576c7913cc21
名前 / ファイル ライセンス アクション
JCR-D-14-01314R1_author_manuscript.pdf JCR-D-14-01314R1_author_manuscript.pdf (1.4 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2015-03-03
タイトル
タイトル Treatment of neurological disorders by introducing mRNA in vivo using polyplex nanomicelles
言語
言語 eng
キーワード
主題Scheme Other
主題 Messenger RNA (mRNA) administration
キーワード
主題Scheme Other
主題 Neurological disorders
キーワード
主題Scheme Other
主題 Olfactory dysfunction
キーワード
主題Scheme Other
主題 Brain-derived neurotrophic factor (BDNF)
キーワード
主題Scheme Other
主題 mRNA-based therapy
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Baba, Miyuki

× Baba, Miyuki

WEKO 2423

Baba, Miyuki

Search repository
Itaka, Keiji

× Itaka, Keiji

WEKO 2424

Itaka, Keiji

Search repository
Kondo, Kenji

× Kondo, Kenji

WEKO 2425

Kondo, Kenji

Search repository
Yamasoba, Tatsuya

× Yamasoba, Tatsuya

WEKO 2426

Yamasoba, Tatsuya

Search repository
Kataoka, Kazunori

× Kataoka, Kazunori

WEKO 2427

Kataoka, Kazunori

Search repository
著者所属
著者所属 Laboratory of Clinical Biotechnology, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo
著者所属
著者所属 Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, The University of Tokyo
著者所属
著者所属 Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo
抄録
内容記述タイプ Abstract
内容記述 Sensory nerve disorders are difficult to cure completely considering poor nerve regeneration capacity and difficulties in accurately targeting neural tissues. Administering mRNA is a promising approach for treating neurological disorders because mRNA can provide proteins and peptides in their native forms for mature non-dividing neural cells, without the need of entering their nuclei. However, direct mRNA administration into neural tissues in vivo has been challenging due to too unstable manner of mRNA and its strong immunogenicity. Thus, using a suitable carrier is essential for effective mRNA administration. For this purpose, we established a novel carrier based on the self-assembly of polyethylene glycol (PEG)–polyamino acid block copolymer, i.e. polyplex nanomicelles. To investigate the feasibility and efficacy of mRNA administration for the treatment of sensory nerve disorders, we used a mouse model of experimentally induced olfactory dysfunction. Intranasal administration of mRNA-loaded nanomicelles provided an efficient and sustained protein expression for nearly two days in nasal tissues, particularly in the lamina propria which contains olfactory nerve fibers, with effectively regulating the immunogenicity of mRNA. Consequently, once-daily intranasal administration of brain-derived neurotrophic factor (BDNF)-expressing mRNA using polyplex nanomicelles remarkably enhanced the neurological recovery of olfactory function along with repairing the olfactory epithelium to a nearly normal architecture. To the best of our knowledge, this is the first study to show the therapeutic potential of introducing exogenous mRNA for the treatment of neurological disorders. These results indicate the feasibility and safety of using mRNA, and provide a novel strategy of mRNA-based therapy.
内容記述
内容記述タイプ Other
内容記述 UTokyo Research掲載「メッセンジャーRNAを用いた新しい遺伝子治療」 URI: http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/a-new-system-of-gene-therapy-using-messenger-rna-mrna.html
内容記述
内容記述タイプ Other
内容記述 UTokyo Research "A new system of gene therapy using messenger RNA (mRNA)" URI: http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/a-new-system-of-gene-therapy-using-messenger-rna-mrna.html
書誌情報 Journal of controlled release

巻 201, p. 41-48, 発行日 2015
ISSN
収録物識別子タイプ ISSN
収録物識別子 0168-3659
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA10458678
DOI
識別子タイプ DOI
関連識別子 info:doi/10.1016/j.jconrel.2015.01.017
権利
権利情報 Copyright (C) 2015 Elsevier B.V. All rights reserved.
著者版フラグ
値 author
出版者
出版者 Elsevier
関係URI
識別子タイプ URI
関連識別子 http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/a-new-system-of-gene-therapy-using-messenger-rna-mrna.html
関係URI
識別子タイプ URI
関連識別子 http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/a-new-system-of-gene-therapy-using-messenger-rna-mrna.html
関係URI
識別子タイプ URI
関連識別子 http://www.sciencedirect.com/science/article/pii/S0168365915000577
戻る
0
views
See details
Views

Versions

Ver.1 2021-03-02 08:46:46.853013
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR 2.0
  • OAI-PMH JPCOAR 1.0
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3