WEKO3
アイテム
BMP Sustains Embryonic Stem Cell Self-Renewal through Distinct Functions of Different Krüppel-like Factors
http://hdl.handle.net/2261/59138
http://hdl.handle.net/2261/5913862f03688-3c55-49df-b4b4-70ec7715b77a
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
1-s2.0-S2213671115003690-main.pdf (3.3 MB)
|
|
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-01-27 | |||||
| タイトル | ||||||
| タイトル | BMP Sustains Embryonic Stem Cell Self-Renewal through Distinct Functions of Different Krüppel-like Factors | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | journal article | |||||
| 著者 |
Morikawa, Masato
× Morikawa, Masato× Koinuma, Daizo× Mizutani, Anna× Kawasaki, Natsumi× Holmborn, Katarina× Sundqvist, Anders× Tsutsumi, Shuichi× Watabe, Tetsuro× Aburatani, Hiroyuki× Heldin, Carl-Henrik× Miyazono, Kohei |
|||||
| 著者所属 | ||||||
| 著者所属 | Ludwig Institute for Cancer Research, Science for Life Laboratory, Uppsala University | |||||
| 著者所属 | ||||||
| 著者所属 | Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo | |||||
| 著者所属 | ||||||
| 著者所属 | Zebrafish Technology Platform, Science for Life Laboratory, Uppsala University | |||||
| 著者所属 | ||||||
| 著者所属 | Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo | |||||
| 著者所属 | ||||||
| 著者所属 | JST, PRESTO | |||||
| 著者所属 | ||||||
| 著者所属 | Present address: Division of Molecular Biotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research | |||||
| 著者所属 | ||||||
| 著者所属 | Present address: Department of Bio-matrix, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Bone morphogenetic protein (BMP) signaling exerts paradoxical roles in pluripotent stem cells (PSCs); it sustains self-renewal of mouse embryonic stem cells (ESCs), while it induces differentiation in other PSCs, including human ESCs. Here, we revisit the roles of BMP-4 using mouse ESCs (mESCs) in naive and primed states. SMAD1 and SMAD5, which transduce BMP signals, recognize enhancer regions together with KLF4 and KLF5 in naive mESCs. KLF4 physically interacts with SMAD1 and suppresses its activity. Consistently, a subpopulation of cells with active BMP-SMAD can be ablated without disturbing the naive state of the culture. Moreover, Smad1/5 doubleknockout mESCs stay in the naive state, indicating that the BMP-SMAD pathway is dispensable for it. In contrast, the MEK5-ERK5 pathway mediates BMP-4-induced self-renewal of mESCs by inducing Klf2, a critical factor for the ground state pluripotency. Our study illustrates that BMP exerts its self-renewing effect through distinct functions of different Kru¨ppel-like factors. | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | UTokyo Research掲載「BMPがマウスES細胞の未分化性を維持する仕組み」 URI: http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/the-roles-of-bmp-signaling-in-mouse-es-cells.html | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | UTokyo Research "The roles of BMP signaling in mouse ES cells" URI: http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/the-roles-of-bmp-signaling-in-mouse-es-cells.html | |||||
| 書誌情報 |
Stem Cell Reports Online Edition 巻 6, 号 1, p. 64-73, 発行日 2016-01-12 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2213-6711 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | info:doi/10.1016/j.stemcr.2015.12.004 | |||||
| 権利 | ||||||
| 権利情報 | Copyright © 2016 The Authors. | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
| 出版者 | ||||||
| 出版者 | Cell Press | |||||
| 関係URI | ||||||
| 関連タイプ | isReferencedBy | |||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.u-tokyo.ac.jp/focus/ja/articles/a_00456.html | |||||
| 関係URI | ||||||
| 関連タイプ | isReferencedBy | |||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.u-tokyo.ac.jp/focus/en/articles/a_00452.html | |||||
| 関係URI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1016/j.stemcr.2015.12.004 | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
