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  1. 112 医学系研究科・医学部
  2. 06 病因・病理学専攻
  3. 1120610 学術雑誌論文
  1. 0 資料タイプ別
  2. 10 学術雑誌論文
  3. 014 自然科学

BMP Sustains Embryonic Stem Cell Self-Renewal through Distinct Functions of Different Krüppel-like Factors

http://hdl.handle.net/2261/59138
62f03688-3c55-49df-b4b4-70ec7715b77a
名前 / ファイル ライセンス アクション
1-s2.0-S2213671115003690-main.pdf 1-s2.0-S2213671115003690-main.pdf (3.3 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2016-01-27
タイトル
タイトル BMP Sustains Embryonic Stem Cell Self-Renewal through Distinct Functions of Different Krüppel-like Factors
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Morikawa, Masato

× Morikawa, Masato

WEKO 2728

Morikawa, Masato

Search repository
Koinuma, Daizo

× Koinuma, Daizo

WEKO 2729

Koinuma, Daizo

Search repository
Mizutani, Anna

× Mizutani, Anna

WEKO 2730

Mizutani, Anna

Search repository
Kawasaki, Natsumi

× Kawasaki, Natsumi

WEKO 2731

Kawasaki, Natsumi

Search repository
Holmborn, Katarina

× Holmborn, Katarina

WEKO 2732

Holmborn, Katarina

Search repository
Sundqvist, Anders

× Sundqvist, Anders

WEKO 2733

Sundqvist, Anders

Search repository
Tsutsumi, Shuichi

× Tsutsumi, Shuichi

WEKO 2734

Tsutsumi, Shuichi

Search repository
Watabe, Tetsuro

× Watabe, Tetsuro

WEKO 2735

Watabe, Tetsuro

Search repository
Aburatani, Hiroyuki

× Aburatani, Hiroyuki

WEKO 2736

Aburatani, Hiroyuki

Search repository
Heldin, Carl-Henrik

× Heldin, Carl-Henrik

WEKO 2737

Heldin, Carl-Henrik

Search repository
Miyazono, Kohei

× Miyazono, Kohei

WEKO 2738

Miyazono, Kohei

Search repository
著者所属
著者所属 Ludwig Institute for Cancer Research, Science for Life Laboratory, Uppsala University
著者所属
著者所属 Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo
著者所属
著者所属 Zebrafish Technology Platform, Science for Life Laboratory, Uppsala University
著者所属
著者所属 Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo
著者所属
著者所属 JST, PRESTO
著者所属
著者所属 Present address: Division of Molecular Biotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research
著者所属
著者所属 Present address: Department of Bio-matrix, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
抄録
内容記述タイプ Abstract
内容記述 Bone morphogenetic protein (BMP) signaling exerts paradoxical roles in pluripotent stem cells (PSCs); it sustains self-renewal of mouse embryonic stem cells (ESCs), while it induces differentiation in other PSCs, including human ESCs. Here, we revisit the roles of BMP-4 using mouse ESCs (mESCs) in naive and primed states. SMAD1 and SMAD5, which transduce BMP signals, recognize enhancer regions together with KLF4 and KLF5 in naive mESCs. KLF4 physically interacts with SMAD1 and suppresses its activity. Consistently, a subpopulation of cells with active BMP-SMAD can be ablated without disturbing the naive state of the culture. Moreover, Smad1/5 doubleknockout mESCs stay in the naive state, indicating that the BMP-SMAD pathway is dispensable for it. In contrast, the MEK5-ERK5 pathway mediates BMP-4-induced self-renewal of mESCs by inducing Klf2, a critical factor for the ground state pluripotency. Our study illustrates that BMP exerts its self-renewing effect through distinct functions of different Kru¨ppel-like factors.
内容記述
内容記述タイプ Other
内容記述 UTokyo Research掲載「BMPがマウスES細胞の未分化性を維持する仕組み」 URI: http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/the-roles-of-bmp-signaling-in-mouse-es-cells.html
内容記述
内容記述タイプ Other
内容記述 UTokyo Research "The roles of BMP signaling in mouse ES cells" URI: http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/the-roles-of-bmp-signaling-in-mouse-es-cells.html
書誌情報 Stem Cell Reports Online Edition

巻 6, 号 1, p. 64-73, 発行日 2016-01-12
ISSN
収録物識別子タイプ ISSN
収録物識別子 2213-6711
DOI
関連識別子
識別子タイプ DOI
関連識別子 info:doi/10.1016/j.stemcr.2015.12.004
権利
権利情報 Copyright © 2016 The Authors.
著者版フラグ
値 publisher
出版者
出版者 Cell Press
関係URI
関連識別子
識別子タイプ URI
関連識別子 http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/the-roles-of-bmp-signaling-in-mouse-es-cells.html
関係URI
関連識別子
識別子タイプ URI
関連識別子 http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/the-roles-of-bmp-signaling-in-mouse-es-cells.html
関係URI
関連識別子
識別子タイプ DOI
関連識別子 http://dx.doi.org/10.1016/j.stemcr.2015.12.004
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