ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

  1. 112 医学系研究科・医学部
  2. 11210 学術雑誌論文
  1. 0 資料タイプ別
  2. 10 学術雑誌論文
  3. 014 自然科学

Calpain-dependent disruption of nucleo-cytoplasmic transport in ALS motor neurons

http://hdl.handle.net/2261/61310
http://hdl.handle.net/2261/61310
36c7ef2f-5ef6-4c38-8e30-81998102b61b
名前 / ファイル ライセンス アクション
srep39994.pdf srep39994.pdf (2.0 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-01-19
タイトル
タイトル Calpain-dependent disruption of nucleo-cytoplasmic transport in ALS motor neurons
言語
言語 eng
キーワード
主題Scheme Other
主題 Amyotrophic lateral sclerosis
キーワード
主題Scheme Other
主題 Molecular neuroscience
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Yamashita, Takenari

× Yamashita, Takenari

WEKO 3847

Yamashita, Takenari

Search repository
Aizawa, Hitoshi

× Aizawa, Hitoshi

WEKO 3848

Aizawa, Hitoshi

Search repository
Teramoto, Sayaka

× Teramoto, Sayaka

WEKO 3849

Teramoto, Sayaka

Search repository
Akamatsu, Megumi

× Akamatsu, Megumi

WEKO 3850

Akamatsu, Megumi

Search repository
Kwak, Shin

× Kwak, Shin

WEKO 3851

Kwak, Shin

Search repository
著者所属
著者所属 Graduate School of Medicine, The University of Tokyo
著者所属
著者所属 Department of Neurology, Tokyo Medical University
著者所属
著者所属 Clinical Research Center for Medicine, International University of Health and Welfare
抄録
内容記述タイプ Abstract
内容記述 Nuclear dysfunction in motor neurons has been hypothesized to be a principal cause of amyotrophic lateral sclerosis (ALS) pathogenesis. Here, we investigated the mechanism by which the nuclear pore complex (NPC) is disrupted in dying motor neurons in a mechanistic ALS mouse model (adenosine deaminase acting on RNA 2 (ADAR2) conditional knockout (AR2) mice) and in ALS patients. We showed that nucleoporins (Nups) that constituted the NPC were cleaved by activated calpain via a Ca2+-permeable AMPA receptor-mediated mechanism in dying motor neurons lacking ADAR2 expression in AR2 mice. In these neurons, nucleo-cytoplasmic transport was disrupted, and the level of the transcript elongation enzyme RNA polymerase II phosphorylated at Ser2 was significantly decreased. Analogous changes were observed in motor neurons lacking ADAR2 immunoreactivity in sporadic ALS patients. Therefore, calpain-dependent NPC disruption may participate in ALS pathogenesis, and inhibiting Ca2+-mediated cell death signals may be a therapeutic strategy for ALS.
内容記述
内容記述タイプ Other
内容記述 UTokyo Research掲載「核と細胞質間の分子輸送経路の破綻が筋萎縮性側索硬化症に関与」 URI: http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/disruption-of-molecule-transport-pathway-between-nucleus-and-cytoplasm-involved-in-als.html
内容記述
内容記述タイプ Other
内容記述 UTokyo Research "Disruption of molecule transport pathway between nucleus and cytoplasm involved in ALS" URI: http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/disruption-of-molecule-transport-pathway-between-nucleus-and-cytoplasm-involved-in-als.html
書誌情報 Scientific Reports Online Edition

巻 7, p. 39994, 発行日 2017-01-03
ISSN
収録物識別子タイプ ISSN
収録物識別子 2045-2322
DOI
識別子タイプ DOI
関連識別子 info:doi/10.1038/srep39994
権利
権利情報 Copyright © 2017, Rights Managed by Nature Publishing Group
著者版フラグ
値 publisher
出版者
出版者 Nature Publishing Group
関係URI
識別子タイプ URI
関連識別子 http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/disruption-of-molecule-transport-pathway-between-nucleus-and-cytoplasm-involved-in-als.html
関係URI
識別子タイプ URI
関連識別子 http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/disruption-of-molecule-transport-pathway-between-nucleus-and-cytoplasm-involved-in-als.html
関係URI
識別子タイプ URI
関連識別子 https://dx.doi.org/10.1038/srep39994
戻る
0
views
See details
Views

Versions

Ver.1 2021-03-02 08:39:47.089610
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR 2.0
  • OAI-PMH JPCOAR 1.0
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3