{"_buckets": {"deposit": "53bd8df2-5830-4b9f-b779-4df5800dddf0"}, "_deposit": {"id": "966", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "966"}, "status": "published"}, "_oai": {"id": "oai:repository.dl.itc.u-tokyo.ac.jp:00000966"}, "item_2_biblio_info_7": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2016-05-14", "bibliographicIssueDateType": "Issued"}, "bibliographic_titles": [{"bibliographic_title": "Human Molecular Genetics Online Edition"}]}]}, "item_2_description_5": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "BIN1 is a genetic risk factor of late-onset Alzheimer disease (AD), which was identified in multiple genome-wide association studies. BIN1 is a member of the amphiphysin family of proteins, and contains N-terminal Bin-Amphiphysin-Rvs and C-terminal Src homology 3 domains. BIN1 is widely expressed in the mouse and human brains, and has been reported to function in the endocytosis and the endosomal sorting of membrane proteins. BACE1 is a type 1 transmembrane aspartyl protease expressed predominantly in neurons of the brain and responsible for the production of amyloid-\u03b2 peptide (A\u03b2). Here we report that the depletion of BIN1 increases cellular BACE1 levels through impaired endosomal trafficking and reduces BACE1 lysosomal degradation, resulting in increased A\u03b2 production. Our findings provide a mechanistic role of BIN1 in the pathogenesis of AD as a novel genetic regulator of BACE1 levels and A\u03b2 production.", "subitem_description_type": "Abstract"}]}, "item_2_description_6": {"attribute_name": "\u5185\u5bb9\u8a18\u8ff0", "attribute_value_mlt": [{"subitem_description": "UTokyo Research\u63b2\u8f09\u300c\u7d30\u80de\u5185\u306e\u8f38\u9001\u306e\u4e71\u308c\u304c\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3092\u5f15\u304d\u8d77\u3053\u3059\u300d URI: http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/disruption-of-intracellular-transport-shown-to-trigger-alzheimers-disease.html", "subitem_description_type": "Other"}, {"subitem_description": "UTokyo Research \"Disruption of intracellular transport shown to trigger Alzheimer\u2019s disease\" URI: http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/disruption-of-intracellular-transport-shown-to-trigger-alzheimers-disease.html", "subitem_description_type": "Other"}]}, "item_2_publisher_20": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Oxford University Press"}]}, "item_2_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "info:doi/10.1093/hmg/ddw146", "subitem_relation_type_select": "DOI"}}]}, "item_2_relation_25": {"attribute_name": "\u95a2\u4fc2URI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/disruption-of-intracellular-transport-shown-to-trigger-alzheimers-disease.html", "subitem_relation_type_select": "URI"}}, {"subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/disruption-of-intracellular-transport-shown-to-trigger-alzheimers-disease.html", "subitem_relation_type_select": "URI"}}, {"subitem_relation_type_id": {"subitem_relation_type_id_text": "http://hmg.oxfordjournals.org/content/early/2016/05/30/hmg.ddw146.abstract", "subitem_relation_type_select": "URI"}}]}, "item_2_rights_12": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "\u00a9 The Author (2016). Published by Oxford University Press on behalf of the Human Molecular Genetics. All rights reserved."}]}, "item_2_select_14": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_2_source_id_10": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA12095462", "subitem_source_identifier_type": "NCID"}]}, "item_2_source_id_8": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1460-2083", "subitem_source_identifier_type": "ISSN"}]}, "item_2_text_34": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"subitem_text_value": "Jounal Article"}]}, "item_2_text_4": {"attribute_name": "\u8457\u8005\u6240\u5c5e", "attribute_value_mlt": [{"subitem_text_value": "Laboratory of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences"}, {"subitem_text_value": "Department of Neurology, Graduate School of Medicine, The University of Tokyo"}, {"subitem_text_value": "Lankenau Institute for Medical Research"}, {"subitem_text_value": "Laboratory of Natural Products Chemistry, Graduate School of Pharmaceutical Sciences, Nagoya University"}, {"subitem_text_value": "Department of Neuropathology, Graduate School of Medicine, The University of Tokyo"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Miyagawa, Toji"}], "nameIdentifiers": [{"nameIdentifier": "3969", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ebinuma, Ihori"}], "nameIdentifiers": [{"nameIdentifier": "3970", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Morohashi, Yuichi"}], "nameIdentifiers": [{"nameIdentifier": "3971", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hori, Yukiko"}], "nameIdentifiers": [{"nameIdentifier": "3972", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Chang, Mee Young"}], "nameIdentifiers": [{"nameIdentifier": "3973", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hattori, Haruhiko"}], "nameIdentifiers": [{"nameIdentifier": "3974", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Maehara, Tomoaki"}], "nameIdentifiers": [{"nameIdentifier": "3975", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yokoshima, Satoshi"}], "nameIdentifiers": [{"nameIdentifier": "3976", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fukuyama, Tohru"}], "nameIdentifiers": [{"nameIdentifier": "3977", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tsuji, Shoji"}], "nameIdentifiers": [{"nameIdentifier": "3978", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Iwatsubo, Takeshi"}], "nameIdentifiers": [{"nameIdentifier": "3979", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Prendergast, George C."}], "nameIdentifiers": [{"nameIdentifier": "3980", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tomita, Taisuke"}], "nameIdentifiers": [{"nameIdentifier": "3981", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-05-30"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "10.1093_hmg_ddw146.pdf", "filesize": [{"value": "2.3 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 2300000.0, "url": {"label": "10.1093_hmg_ddw146.pdf", "url": "https://repository.dl.itc.u-tokyo.ac.jp/record/966/files/10.1093_hmg_ddw146.pdf"}, "version_id": "4ef9f67f-1cfd-4b59-973a-6ee368c39953"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "BIN1 regulates BACE1 intracellular trafficking and amyloid-\u03b2 production", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "BIN1 regulates BACE1 intracellular trafficking and amyloid-\u03b2 production"}]}, "item_type_id": "2", "owner": "1", "path": ["9/10/11", "20/229/230"], "permalink_uri": "http://hdl.handle.net/2261/72467", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_name_i18n": "\u516c\u958b\u65e5", "attribute_value": "2017-05-15"}, "publish_date": "2017-05-15", "publish_status": "0", "recid": "966", "relation": {}, "relation_version_is_last": true, "title": ["BIN1 regulates BACE1 intracellular trafficking and amyloid-\u03b2 production"], "weko_shared_id": null}