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Single ingestion of soy β-conglycinin induces increased postprandial circulating FGF21 levels exerting beneficial health effects
http://hdl.handle.net/2261/59542
http://hdl.handle.net/2261/595423173dded-3387-43fe-9eaa-151bc2294480
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
srep28183.pdf (2.1 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2016-07-14 | |||||
| タイトル | ||||||
| タイトル | Single ingestion of soy β-conglycinin induces increased postprandial circulating FGF21 levels exerting beneficial health effects | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Metabolic syndrome | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Molecular biology | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Obesity | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Proteins | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | journal article | |||||
| 著者 |
Hashidume, Tsutomu
× Hashidume, Tsutomu× Kato, Asuka× Tanaka, Tomohiro× Miyoshi, Shoko× Itoh, Nobuyuki× Nakata, Rieko× Inoue, Hiroyasu× Oikawa, Akira× Nakai, Yuji× Shimizu, Makoto× Inoue, Jun× Sato, Ryuichiro |
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| 著者所属 | ||||||
| 著者所属 | Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo | |||||
| 著者所属 | ||||||
| 著者所属 | Institute of Gerontology, The University of Tokyo | |||||
| 著者所属 | ||||||
| 著者所属 | Medical Innovation Center, Kyoto University Graduate School of Medicine | |||||
| 著者所属 | ||||||
| 著者所属 | Department of Food Science and Nutrition, Nara Women’s University | |||||
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| 著者所属 | RIKEN Center for Sustainable Resource Science | |||||
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| 著者所属 | Faculty of Agriculture, Yamagata University | |||||
| 著者所属 | ||||||
| 著者所属 | Institute for Food Science, Hirosaki University | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Soy protein β-conglycinin has serum lipid-lowering and anti-obesity effects. We showed that single ingestion of β-conglycinin after fasting alters gene expression in mouse liver. A sharp increase in fibroblast growth factor 21 (FGF21) gene expression, which is depressed by normal feeding, resulted in increased postprandial circulating FGF21 levels along with a significant decrease in adipose tissue weights. Most increases in gene expressions, including FGF21, were targets for the activating transcription factor 4 (ATF4), but not for peroxisome proliferator-activated receptor α. Overexpression of a dominant-negative form of ATF4 significantly reduced β-conglycinin-induced increases in hepatic FGF21 gene expression. In FGF21-deficient mice, β-conglycinin effects were partially abolished. Methionine supplementation to the diet or primary hepatocyte culture medium demonstrated its importance for activating liver or hepatocyte ATF4-FGF21 signaling. Thus, dietary β-conglycinin intake can impact hepatic and systemic metabolism by increasing the postprandial circulating FGF21 levels. | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | UTokyo Research掲載「大豆のタンパク質1回摂取で代謝を改善する因子が急増」 URI: http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/single-ingestion-of-soy-protein-improves-metabolism.html | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | UTokyo Research "Single ingestion of soy protein improves metabolism" URI: http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/single-ingestion-of-soy-protein-improves-metabolism.html | |||||
| 書誌情報 |
Scientific Reports 巻 6, p. 28183, 発行日 2016-06-17 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 20452322 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | info:doi/10.1038/srep28183 | |||||
| 権利 | ||||||
| 権利情報 | Copyright © 2016, Rights Managed by Nature Publishing Group | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
| 出版者 | ||||||
| 出版者 | Nature Publishing Group | |||||
| 関係URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/single-ingestion-of-soy-protein-improves-metabolism.html | |||||
| 関係URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/single-ingestion-of-soy-protein-improves-metabolism.html | |||||
| 関係URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.nature.com/articles/srep28183 | |||||
