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サル免疫不全ウイルス・カプシド蛋白の分子間N-Cドメインの機能的相互作用に重要なアミノ酸配列に関する研究
https://doi.org/10.15083/00004077
d00f562a-7a62-4d57-8da4-0e886ee1d25b
| 名前 / ファイル | ライセンス | アクション | |
|---|---|---|---|
h22_inagaki.pdf (2.6 MB)
|
|
| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-11-08 | |||||
| タイトル | ||||||
| タイトル | サル免疫不全ウイルス・カプシド蛋白の分子間N-Cドメインの機能的相互作用に重要なアミノ酸配列に関する研究 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_46ec | |||||
| タイプ | thesis | |||||
| ID登録 | ||||||
| ID登録 | 10.15083/00004077 | |||||
| ID登録タイプ | JaLC | |||||
| 著者 |
稲垣, 奈都子
× 稲垣, 奈都子 |
|||||
| 著者別名 | ||||||
| 識別子 | ||||||
| 識別子 | 9416 | |||||
| 識別子Scheme | WEKO | |||||
| 姓名 | ||||||
| 姓名 | いながき, なつこ | |||||
| 著者所属 | ||||||
| 東京大学大学院医学系研究科病因・病理学専攻 | ||||||
| Abstract | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | 多様性の高いゲノムを有するエイズウイルスの中で比較的保存性が高いゲノム領域にコードされるGagカプシドタンパク(CA)の構造上の制約を知ることは、ワクチン抗原デザインや抗HIV薬開発に有用である。私は細胞傷害性Tリンパ球の認識に影響するCAの1アミノ酸置換を有する変異体の解析を行い、CAのN末端ドメイン内のある1アミノ酸とC末端ドメイン内の1アミノ酸の相互作用がウイルス複製に重要であることをin vitroおよびin vivoの両視点から明らかにした。本研究は、CAドメイン間の機能的相互作用のための構造上の制約を提示するものである。 | |||||
| 書誌情報 | 発行日 2011-03-24 | |||||
| 日本十進分類法 | ||||||
| 主題 | 490 | |||||
| 主題Scheme | NDC | |||||
| 学位名 | ||||||
| 学位名 | 博士(医学) | |||||
| 学位 | ||||||
| 値 | doctoral | |||||
| 学位分野 | ||||||
| Medical Science(医学) | ||||||
| 学位授与機関 | ||||||
| 学位授与機関名 | ||||||
| 学位授与機関名 | University of Tokyo (東京大学) | |||||
| 研究科・専攻 | ||||||
| Department of Pathology, Immunology and Microbiology, Graduate School of Medicine (医学系研究科病因・病理学専攻) | ||||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2011-03-24 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲第26983号 | |||||
| 学位記番号 | ||||||
| 博医第3593号 | ||||||
