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Activation-induced cytidine deaminase(AID)を介するメシル酸イマチニブのB細胞分化抑制作用の解析
https://doi.org/10.15083/00005469
d7fc0e54-3d07-4c04-9761-c53b3b1cfa6a
名前 / ファイル | ライセンス | アクション | |
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2014-01-14 | |||||
タイトル | ||||||
タイトル | Activation-induced cytidine deaminase(AID)を介するメシル酸イマチニブのB細胞分化抑制作用の解析 | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_46ec | |||||
タイプ | thesis | |||||
ID登録 | ||||||
ID登録 | 10.15083/00005469 | |||||
ID登録タイプ | JaLC | |||||
著者 |
川俣, 豊隆
× 川俣, 豊隆 |
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著者所属 | ||||||
著者所属 | 東京大学医学系研究科内科学専攻 | |||||
Abstract | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Activation-induced cytidine deaminase(AID)は、活性化B細胞における体細胞突然変異(SHM)や、クラススイッチ組換え(CSR)に必須の酵素である。AIDの過剰発現が、異常な体細胞突然変異や染色体転座を惹起し、腫瘍形成へ関与する。メシル酸イマチニブ(IM)は、慢性骨髄性白血病の原因遺伝子であるBCR-ABL融合遺伝子の産物に対する分子標的薬である。IM投与中に免疫グロブリン値の低下をしばしば認めるが、その機序は明らかではない。今回私は、IMがAIDの抑制を介したCSR抑制作用を有し、AID発現調節因子の中でも特にE2Aが重要な役割を果たしていることを示した。 | |||||
書誌情報 | 発行日 2013-03-25 | |||||
学位名 | ||||||
学位名 | 博士(医学) | |||||
学位 | ||||||
値 | doctoral | |||||
学位分野 | ||||||
Medical Science(医学) | ||||||
学位授与機関 | ||||||
学位授与機関名 | ||||||
学位授与機関名 | University of Tokyo (東京大学) | |||||
研究科・専攻 | ||||||
Department of Internal Medicine, Graduate School of Medicine(医学系研究科内科学専攻) | ||||||
学位授与年月日 | ||||||
学位授与年月日 | 2013-03-25 |