{"_buckets": {"deposit": "0a591643-2f9c-4cc8-94f9-590a7d1e3762"}, "_deposit": {"id": "5605", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "5605"}, "status": "published"}, "_oai": {"id": "oai:repository.dl.itc.u-tokyo.ac.jp:00005605"}, "item_7_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "\u306a\u305c\u611f\u67d3\u3067\u6b7b\u306c\u306e\u304b?\u611f\u67d3\u306e\u96c6\u56e3\u751f\u7269\u5b66\u306e\u300c\u5b9f\u9a13+\u6570\u7406\u300d\u89e3\u6790\u7cfb\u306e\u5275\u51fa"}]}, "item_7_biblio_info_7": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2012-03-22", "bibliographicIssueDateType": "Issued"}, "bibliographic_titles": [{}]}]}, "item_7_date_granted_25": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u5e74\u6708\u65e5", "attribute_value_mlt": [{"subitem_dategranted": "2012-03-22"}]}, "item_7_degree_grantor_23": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u6a5f\u95a2", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "University of Tokyo (\u6771\u4eac\u5927\u5b66)"}]}]}, "item_7_degree_name_20": {"attribute_name": "\u5b66\u4f4d\u540d", "attribute_value_mlt": [{"subitem_degreename": "\u535a\u58eb(\u751f\u547d\u79d1\u5b66)"}]}, "item_7_description_5": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Why do some organisms succumb and die easily when infected? Microbial infection often leads to expression of virulence and host death when symbiosis seems more beneficial for the infecting microbe\u0027s maintenance. Previously proposed explanations have focused on the pathogen\u0027s side. In this work, I tested a hypothesis focused on the host strategy. If a member of a host population dies immediately upon infection with a pathogen, thereby ending its reproduction, then its death could protect the host population from secondary and further infections. I tested this \"Suicidal Defense Against Infection\" (SDAI) hypothesis by developing an experimental infection system that involves a huge number of bacterial cells as host and their virus as pathogen and is linked to mathematical modeling. I prepared two host strains, one with the SDAI strategy (type A) and the other without (type S), mixed them at varying ratios, challenged them with the pathogen and monitored any change in the ratio during infection. I used two conditions for infection: standing solid agar providing spatial structure, thereby ensuring that individuals preferentially interact with their neighbors, and well-mixed liquid lacking spatial structure. I found that the SDAI strategy has great advantage in the presence of spatial structure: Pathogen increase was accompanied by a large increase in the A:S ratio. In contrast, there was a decrease in the A:S ratio in the absence of spatial structure. My simulation reproduced the essential features of the experimental results. These results provide a new perspective for understanding host-pathogen interaction.", "subitem_description_type": "Abstract"}]}, "item_7_dissertation_number_26": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u756a\u53f7", "attribute_value_mlt": [{"subitem_dissertationnumber": "\u7532\u7b2c28421\u53f7"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "11668", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "\u798f\u4e16, \u771f\u6a39"}]}]}, "item_7_identifier_registration": {"attribute_name": "ID\u767b\u9332", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.15083/00005596", "subitem_identifier_reg_type": "JaLC"}]}, "item_7_select_21": {"attribute_name": "\u5b66\u4f4d", "attribute_value_mlt": [{"subitem_select_item": "doctoral"}]}, "item_7_subject_13": {"attribute_name": "\u65e5\u672c\u5341\u9032\u5206\u985e\u6cd5", "attribute_value_mlt": [{"subitem_subject": "491", "subitem_subject_scheme": "NDC"}]}, "item_7_text_22": {"attribute_name": "\u5b66\u4f4d\u5206\u91ce", "attribute_value_mlt": [{"subitem_text_value": "Integrated Biosciences (\u751f\u547d\u79d1\u5b66)"}]}, "item_7_text_24": {"attribute_name": "\u7814\u7a76\u79d1\u30fb\u5c02\u653b", "attribute_value_mlt": [{"subitem_text_value": "Department of Medical Genome Sciences, Graduate School of Frontier Sciences (\u65b0\u9818\u57df\u5275\u6210\u79d1\u5b66\u7814\u7a76\u79d1\u30e1\u30c7\u30a3\u30ab\u30eb\u30b2\u30ce\u30e0\u5c02\u653b)"}]}, "item_7_text_27": {"attribute_name": "\u5b66\u4f4d\u8a18\u756a\u53f7", "attribute_value_mlt": [{"subitem_text_value": "\u535a\u5275\u57df\u7b2c780\u53f7"}]}, "item_7_text_36": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"subitem_text_value": "Thesis"}]}, "item_7_text_4": {"attribute_name": "\u8457\u8005\u6240\u5c5e", "attribute_value_mlt": [{"subitem_text_value": "\u6771\u4eac\u5927\u5b66\u5927\u5b66\u9662\u65b0\u9818\u57df\u5275\u6210\u79d1\u5b66\u7814\u7a76\u79d1\u751f\u547d\u79d1\u5b66\u7814\u7a76\u7cfb\u30e1\u30c7\u30a3\u30ab\u30eb\u30b2\u30ce\u30e0\u5c02\u653b"}, {"subitem_text_value": "Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Fukuyo, Masaki"}], "nameIdentifiers": [{"nameIdentifier": "11667", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-06-01"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "K-03561.pdf", "filesize": [{"value": "1.6 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1600000.0, "url": {"label": "K-03561.pdf", "url": "https://repository.dl.itc.u-tokyo.ac.jp/record/5605/files/K-03561.pdf"}, "version_id": "aeb830c6-ed2f-4dac-b303-af9765a343b9"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "\u611f\u67d3", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u6bd2\u6027", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u5229\u4ed6\u884c\u52d5", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "thesis", "resourceuri": "http://purl.org/coar/resource_type/c_46ec"}]}, "item_title": "Success of a suicidal defense strategy against infection in a structured habitat", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Success of a suicidal defense strategy against infection in a structured habitat"}]}, "item_type_id": "7", "owner": "1", "path": ["9/233/280", "110/267/345"], "permalink_uri": "https://doi.org/10.15083/00005596", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2014-02-24"}, "publish_date": "2014-02-24", "publish_status": "0", "recid": "5605", "relation": {}, "relation_version_is_last": true, "title": ["Success of a suicidal defense strategy against infection in a structured habitat"], "weko_shared_id": null}