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Protective effect of the long pentraxin PTX3 against histone-mediated endothelial cell cytotoxicity in sepsis
http://hdl.handle.net/2261/56112
http://hdl.handle.net/2261/561128fddd646-4a7b-46d7-8719-e09931b9770f
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Sci_Signal-7_343_ra88_author.pdf (675.8 kB)
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| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2015-02-04 | |||||
| タイトル | ||||||
| タイトル | Protective effect of the long pentraxin PTX3 against histone-mediated endothelial cell cytotoxicity in sepsis | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | journal article | |||||
| 著者 |
Daigo, Kenji
× Daigo, Kenji× Nakakido, Makoto× Ohashi, Riuko× Fukuda, Rie× Matsubara, Koichi× Minami, Takashi× Yamaguchi, Naotaka× Inoue, Kenji× Jiang, Shuying× Naito, Makoto× Tsumoto, Kouhei× Hamakubo, Takao |
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| 著者所属 | ||||||
| 著者所属 | Department of Quantitative Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo | |||||
| 著者所属 | ||||||
| 著者所属 | Laboratory of Medical Proteomics, Institute of Medical Science, The University of Tokyo | |||||
| 著者所属 | ||||||
| 著者所属 | Division of Cellular and Molecular Pathology, Department of Cellular Function, Niigata University Graduate School of Medical and Dental Sciences | |||||
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| 著者所属 | Department of Pathology, Niigata University Medical and Dental Hospital | |||||
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| 著者所属 | Laboratory for Vascular Biology, Research Center for Advanced Science and Technology, The University of Tokyo | |||||
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| 著者所属 | Department of Emergency and Critical Care Medicine, Juntendo University Nerima Hospital | |||||
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| 著者所属 | Department of Cardiology, Juntendo University Nerima Hospital | |||||
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| 著者所属 | Niigata College of Medical Technology | |||||
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| 著者所属 | Perseus Proteomics Inc. | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Pentraxin 3 (PTX3), a member of the long pentraxin subfamily within the family of pentraxins, is a soluble pattern recognition molecule that functions in the innate immune system. Innate immunity affords the infected host protection against sepsis, a potentially life-threatening inflammatory response to infection. Extracellular histones are considered to be the main cause of septic death because of their cytotoxic effect on endothelial cells, which makes them a potential therapeutic target. We found that PTX3 interacted with histones to form coaggregates, which depended on polyvalent interactions and disorder in the secondary structure of PTX3. PTX3 exerted a protective effect, both in vitro and in vivo, against histone-mediated cytotoxicity toward endothelial cells. Additionally, the intraperitoneal administration of PTX3 reduced mortality in mouse models of sepsis. The amino-terminal domain of PTX3, which was required for coaggregation with histones, was sufficient to protect against cytotoxicity. Our results suggest that the host-protective effects of PTX3 in sepsis are a result of its coaggregation with histones rather than its ability to mediate pattern recognition. This long pentraxin–specific effect provides a potential basis for the treatment of sepsis directed at protecting cells from the toxic effects of extracellular histones. | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | UTokyo Research掲載「ペントラキシン３の敗血症への効果を発見」 URI: http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/host-protective-effect-of-pentraxin-3-in-sepsis/ | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | UTokyo Research "Host-protective effect of pentraxin 3 in sepsis" URI: http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/host-protective-effect-of-pentraxin-3-in-sepsis/ | |||||
| bibliographic_information |
Science signaling 巻 7, 号 343, p. ra88, 発行日 2014-09-16 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1945-0877 | |||||
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| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1937-9145 | |||||
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| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA12315525 | |||||
| item_2_relation_11 | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | info:doi/10.1126/scisignal.2005522 | |||||
| 権利 | ||||||
| 権利情報 | © 2014 Authors. | |||||
| item_2_select_14 | ||||||
| 値 | author | |||||
| 出版者 | ||||||
| 出版者 | American Association for the Advancement of Science | |||||
| 関係URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/host-protective-effect-of-pentraxin-3-in-sepsis/ | |||||
| 関係URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/host-protective-effect-of-pentraxin-3-in-sepsis/ | |||||
| 関係URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://stke.sciencemag.org/content/7/343/ra88.abstract | |||||
