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Rad54B serves as a scaffold in the DNA damage response that limits checkpoint strength
http://hdl.handle.net/2261/56874
http://hdl.handle.net/2261/56874232c9d39-fb65-4d1e-a31c-de9d00ea0de7
名前 / ファイル | ライセンス | アクション |
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ncomms6426_author_version.pdf (3.8 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2015-05-13 | |||||
タイトル | ||||||
タイトル | Rad54B serves as a scaffold in the DNA damage response that limits checkpoint strength | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Yasuhara, Takaaki
× Yasuhara, Takaaki× Suzuki, Takahiko× Katsura, Mari× Miyagawa, Kiyoshi |
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著者所属 | ||||||
著者所属 | Laboratory of Molecular Radiology, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo | |||||
著者所属 | ||||||
著者所属 | Department of Radiological Technology, Faculty of Medical Technology, Teikyo University | |||||
著者所属 | ||||||
著者所属 | Isotope Science Center, The University of Tokyo | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The strength of the DNA damage checkpoint critically influences cell fate, yet the mechanisms behind the fine tuning of checkpoint strength during the DNA damage response (DDR) are poorly understood. Here we show that Rad54B—a SNF2 helicase-like DNA-repair protein—limits the strength of both the G1/S and G2/M checkpoints. We find that Rad54B functions as a scaffold for p53 degradation via its direct interaction with the MDM2–MDMX ubiquitin–ligase complex. During the early phases of the DDR, Rad54B is upregulated, thereby maintaining low checkpoint strength and facilitating cell cycle progression. Once the p53-mediated checkpoint is established, Rad54B is downregulated, and high checkpoint strength is maintained. Constitutive upregulation of Rad54B activity, which is frequently observed in tumours, promotes genomic instability because of checkpoint override. Thus, the scaffolding function of Rad54B dynamically regulates the maintenance of genome integrity by limiting checkpoint strength. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | UTokyo Research掲載「がん発生の基盤となる仕組みを探る」 URI: http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/discovery-of-a-basic-mechanism-of-cancer-development/ | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | UTokyo Research "Discovery of a basic mechanism of cancer development" URI: http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/discovery-of-a-basic-mechanism-of-cancer-development/ | |||||
書誌情報 |
Nature communications 巻 5, p. 5426, 発行日 2014-11-11 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2041-1723 | |||||
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収録物識別子タイプ | NCID | |||||
収録物識別子 | AA12645905 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1038/ncomms6426 | |||||
権利 | ||||||
権利情報 | Copyright (C) 2014, Rights Managed by Nature Publishing Group | |||||
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値 | author | |||||
出版者 | ||||||
出版者 | Nature Publishing Group | |||||
関係URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/discovery-of-a-basic-mechanism-of-cancer-development/ | |||||
関係URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/discovery-of-a-basic-mechanism-of-cancer-development/ | |||||
関係URI | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.nature.com/ncomms/2014/141111/ncomms6426/abs/ncomms6426.html |