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  1. 112 医学系研究科・医学部
  2. 50 疾患生命工学センター
  3. 1125010 学術雑誌論文
  1. 0 資料タイプ別
  2. 10 学術雑誌論文
  3. 014 自然科学

Rad54B serves as a scaffold in the DNA damage response that limits checkpoint strength

http://hdl.handle.net/2261/56874
232c9d39-fb65-4d1e-a31c-de9d00ea0de7
名前 / ファイル ライセンス アクション
ncomms6426_author_version.pdf ncomms6426_author_version.pdf (3.8 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2015-05-13
タイトル
タイトル Rad54B serves as a scaffold in the DNA damage response that limits checkpoint strength
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Yasuhara, Takaaki

× Yasuhara, Takaaki

WEKO 2472

Yasuhara, Takaaki

Search repository
Suzuki, Takahiko

× Suzuki, Takahiko

WEKO 2473

Suzuki, Takahiko

Search repository
Katsura, Mari

× Katsura, Mari

WEKO 2474

Katsura, Mari

Search repository
Miyagawa, Kiyoshi

× Miyagawa, Kiyoshi

WEKO 2475

Miyagawa, Kiyoshi

Search repository
著者所属
著者所属 Laboratory of Molecular Radiology, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo
著者所属
著者所属 Department of Radiological Technology, Faculty of Medical Technology, Teikyo University
著者所属
著者所属 Isotope Science Center, The University of Tokyo
抄録
内容記述タイプ Abstract
内容記述 The strength of the DNA damage checkpoint critically influences cell fate, yet the mechanisms behind the fine tuning of checkpoint strength during the DNA damage response (DDR) are poorly understood. Here we show that ​Rad54B—a SNF2 helicase-like DNA-repair protein—limits the strength of both the G1/S and G2/M checkpoints. We find that ​Rad54B functions as a scaffold for ​p53 degradation via its direct interaction with the ​MDM2–​MDMX ubiquitin–ligase complex. During the early phases of the DDR, ​Rad54B is upregulated, thereby maintaining low checkpoint strength and facilitating cell cycle progression. Once the ​p53-mediated checkpoint is established, ​Rad54B is downregulated, and high checkpoint strength is maintained. Constitutive upregulation of ​Rad54B activity, which is frequently observed in tumours, promotes genomic instability because of checkpoint override. Thus, the scaffolding function of ​Rad54B dynamically regulates the maintenance of genome integrity by limiting checkpoint strength.
内容記述
内容記述タイプ Other
内容記述 UTokyo Research掲載「がん発生の基盤となる仕組みを探る」 URI: http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/discovery-of-a-basic-mechanism-of-cancer-development/
内容記述
内容記述タイプ Other
内容記述 UTokyo Research "Discovery of a basic mechanism of cancer development" URI: http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/discovery-of-a-basic-mechanism-of-cancer-development/
書誌情報 Nature communications

巻 5, p. 5426, 発行日 2014-11-11
ISSN
収録物識別子タイプ ISSN
収録物識別子 2041-1723
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA12645905
DOI
関連識別子
識別子タイプ DOI
関連識別子 info:doi/10.1038/ncomms6426
権利
権利情報 Copyright (C) 2014, Rights Managed by Nature Publishing Group
著者版フラグ
値 author
出版者
出版者 Nature Publishing Group
関係URI
関連識別子
識別子タイプ URI
関連識別子 http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/discovery-of-a-basic-mechanism-of-cancer-development/
関係URI
関連識別子
識別子タイプ URI
関連識別子 http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/discovery-of-a-basic-mechanism-of-cancer-development/
関係URI
関連識別子
識別子タイプ URI
関連識別子 http://www.nature.com/ncomms/2014/141111/ncomms6426/abs/ncomms6426.html
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