{"_buckets": {"deposit": "cefc3bab-0ab4-40ba-b3e9-12074c9fc23a"}, "_deposit": {"id": "684", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "684"}, "status": "published"}, "_oai": {"id": "oai:repository.dl.itc.u-tokyo.ac.jp:00000684"}, "item_2_biblio_info_7": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2014-11-11", "bibliographicIssueDateType": "Issued"}, "bibliographicPageStart": "5426", "bibliographicVolumeNumber": "5", "bibliographic_titles": [{"bibliographic_title": "Nature communications"}]}]}, "item_2_description_5": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "The strength of the DNA damage checkpoint critically influences cell fate, yet the mechanisms behind the fine tuning of checkpoint strength during the DNA damage response (DDR) are poorly understood. Here we show that \u200bRad54B\u2014a SNF2 helicase-like DNA-repair protein\u2014limits the strength of both the G1/S and G2/M checkpoints. We find that \u200bRad54B functions as a scaffold for \u200bp53 degradation via its direct interaction with the \u200bMDM2\u2013\u200bMDMX ubiquitin\u2013ligase complex. During the early phases of the DDR, \u200bRad54B is upregulated, thereby maintaining low checkpoint strength and facilitating cell cycle progression. Once the \u200bp53-mediated checkpoint is established, \u200bRad54B is downregulated, and high checkpoint strength is maintained. Constitutive upregulation of \u200bRad54B activity, which is frequently observed in tumours, promotes genomic instability because of checkpoint override. Thus, the scaffolding function of \u200bRad54B dynamically regulates the maintenance of genome integrity by limiting checkpoint strength.", "subitem_description_type": "Abstract"}]}, "item_2_description_6": {"attribute_name": "\u5185\u5bb9\u8a18\u8ff0", "attribute_value_mlt": [{"subitem_description": "UTokyo Research\u63b2\u8f09\u300c\u304c\u3093\u767a\u751f\u306e\u57fa\u76e4\u3068\u306a\u308b\u4ed5\u7d44\u307f\u3092\u63a2\u308b\u300d URI: http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/discovery-of-a-basic-mechanism-of-cancer-development/", "subitem_description_type": "Other"}, {"subitem_description": "UTokyo Research \"Discovery of a basic mechanism of cancer development\" URI: http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/discovery-of-a-basic-mechanism-of-cancer-development/", "subitem_description_type": "Other"}]}, "item_2_publisher_20": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Nature Publishing Group"}]}, "item_2_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "info:doi/10.1038/ncomms6426", "subitem_relation_type_select": "DOI"}}]}, "item_2_relation_25": {"attribute_name": "\u95a2\u4fc2URI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/discovery-of-a-basic-mechanism-of-cancer-development/", "subitem_relation_type_select": "URI"}}, {"subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/discovery-of-a-basic-mechanism-of-cancer-development/", "subitem_relation_type_select": "URI"}}, {"subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.nature.com/ncomms/2014/141111/ncomms6426/abs/ncomms6426.html", "subitem_relation_type_select": "URI"}}]}, "item_2_rights_12": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "Copyright (C) 2014, Rights Managed by Nature Publishing Group"}]}, "item_2_select_14": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_2_source_id_10": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA12645905", "subitem_source_identifier_type": "NCID"}]}, "item_2_source_id_8": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "2041-1723", "subitem_source_identifier_type": "ISSN"}]}, "item_2_text_34": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"subitem_text_value": "Jounal Article"}]}, "item_2_text_4": {"attribute_name": "\u8457\u8005\u6240\u5c5e", "attribute_value_mlt": [{"subitem_text_value": "Laboratory of Molecular Radiology, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo"}, {"subitem_text_value": "Department of Radiological Technology, Faculty of Medical Technology, Teikyo University"}, {"subitem_text_value": "Isotope Science Center, The University of Tokyo"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Yasuhara, Takaaki"}], "nameIdentifiers": [{"nameIdentifier": "2472", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suzuki, Takahiko"}], "nameIdentifiers": [{"nameIdentifier": "2473", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Katsura, Mari"}], "nameIdentifiers": [{"nameIdentifier": "2474", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Miyagawa, Kiyoshi"}], "nameIdentifiers": [{"nameIdentifier": "2475", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-05-30"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "ncomms6426_author_version.pdf", "filesize": [{"value": "3.8 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 3800000.0, "url": {"label": "ncomms6426_author_version.pdf", "url": "https://repository.dl.itc.u-tokyo.ac.jp/record/684/files/ncomms6426_author_version.pdf"}, "version_id": "e7716cfc-4e93-45bd-af7e-dc62fce1ee70"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Rad54B serves as a scaffold in the DNA damage response that limits checkpoint strength", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Rad54B serves as a scaffold in the DNA damage response that limits checkpoint strength"}]}, "item_type_id": "2", "owner": "1", "path": ["9/10/11", "125/163/164"], "permalink_uri": "http://hdl.handle.net/2261/56874", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2015-05-13"}, "publish_date": "2015-05-13", "publish_status": "0", "recid": "684", "relation": {}, "relation_version_is_last": true, "title": ["Rad54B serves as a scaffold in the DNA damage response that limits checkpoint strength"], "weko_shared_id": 2}