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  1. 116 農学生命科学研究科・農学部
  2. 22 応用動物科学専攻
  3. 1162210 学術雑誌論文
  1. 0 資料タイプ別
  2. 10 学術雑誌論文
  3. 014 自然科学

Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity

http://hdl.handle.net/2261/58609
http://hdl.handle.net/2261/58609
994ae7cb-1e5a-4612-975c-2dacd4ade20d
名前 / ファイル ライセンス アクション
ncomms7780_author_version.pdf ncomms7780_author_version.pdf (3.1 MB)
ncomms7780_supplementary_author_version.pdf ncomms7780_supplementary_author_version.pdf (2.7 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2015-10-20
タイトル
タイトル Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity
言語
言語 eng
キーワード
主題Scheme Other
主題 Biological sciences
キーワード
主題Scheme Other
主題 Cell biology
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Fukushima, Toshiaki

× Fukushima, Toshiaki

WEKO 2635

Fukushima, Toshiaki

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Yoshihara, Hidehito

× Yoshihara, Hidehito

WEKO 2636

Yoshihara, Hidehito

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Furuta, Haruka

× Furuta, Haruka

WEKO 2637

Furuta, Haruka

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Kamei, Hiroyasu

× Kamei, Hiroyasu

WEKO 2638

Kamei, Hiroyasu

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Hakuno, Fumihiko

× Hakuno, Fumihiko

WEKO 2639

Hakuno, Fumihiko

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Luan, Jing

× Luan, Jing

WEKO 2640

Luan, Jing

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Duan, Cunming

× Duan, Cunming

WEKO 2641

Duan, Cunming

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Saeki, Yasushi

× Saeki, Yasushi

WEKO 2642

Saeki, Yasushi

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Tanaka, Keiji

× Tanaka, Keiji

WEKO 2643

Tanaka, Keiji

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Iemura, Shun-Ichiro

× Iemura, Shun-Ichiro

WEKO 2644

Iemura, Shun-Ichiro

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Natsume, Tohru

× Natsume, Tohru

WEKO 2645

Natsume, Tohru

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Chida, Kazuhiro

× Chida, Kazuhiro

WEKO 2646

Chida, Kazuhiro

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Nakatsu, Yusuke

× Nakatsu, Yusuke

WEKO 2647

Nakatsu, Yusuke

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Kamata, Hideaki

× Kamata, Hideaki

WEKO 2648

Kamata, Hideaki

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Asano, Tomoichiro

× Asano, Tomoichiro

WEKO 2649

Asano, Tomoichiro

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Takahashi, Shin-Ichiro

× Takahashi, Shin-Ichiro

WEKO 2650

Takahashi, Shin-Ichiro

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著者所属
著者所属 Departments of Animal Sciences and Applied Biological Chemistry, Graduate School of Agriculture and Life Sciences, The University of Tokyo
著者所属
著者所属 Department of Medical Science, Graduate School of Medicine, Hiroshima University
著者所属
著者所属 Laboratory of Protein Metabolism, Tokyo Metropolitan Institute of Medical Science
著者所属
著者所属 Key Laboratory of Marine Drugs, Chinese Ministry of Education, Ocean University of China
著者所属
著者所属 Department of Molecular, Cellular and Developmental Biology, University of Michigan
著者所属
著者所属 Molecular Profiling Research Center for Drug Discovery (molprof), National Institute of Advanced Industrial Science and Technology (AIST)
抄録
内容記述タイプ Abstract
内容記述 Insulin-like growth factors (IGFs) induce proliferation of various cell types and play important roles in somatic growth and cancer development. Phosphorylation of insulin receptor substrate (IRS)-1/2 by IGF-I receptor tyrosine kinase is essential for IGF action. Here we identify Nedd4 as an IRS-2 ubiquitin ligase. Nedd4 monoubiquitinates IRS-2, which promotes its association with Epsin1, a ubiquitin-binding protein. Nedd4 recruits IRS-2 to the membrane, probably through promoting Epsin1 binding, and enhances IGF-I receptor-induced IRS-2 tyrosine phosphorylation. In thyroid FRTL-5 cells, activation of the cyclic AMP pathway increases the association of Nedd4 with IRS-2, thereby enhancing IRS-2-mediated signalling and cell proliferation induced by IGF-I. The Nedd4 and IRS-2 association is also required for maximal activation of IGF-I signalling and cell proliferation in prostate cancer PC-3 cells. Nedd4 overexpression accelerates zebrafish embryonic growth through IRS-2 in vivo. We conclude that Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity.
内容記述
内容記述タイプ Other
内容記述 UTokyo Research掲載「動物の成長や細胞の増殖の新しい調節機構を発見」 URI: http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/novel-regulatory-mechanisms-of-animal-growth-and-cell-proliferation.html
内容記述
内容記述タイプ Other
内容記述 UTokyo Research "Novel regulatory mechanisms of animal growth and cell proliferation" URI: http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/novel-regulatory-mechanisms-of-animal-growth-and-cell-proliferation.html
書誌情報 Nature communications

巻 6, p. 6780, 発行日 2015-04-15
ISSN
収録物識別子タイプ ISSN
収録物識別子 20411723
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA12645905
DOI
識別子タイプ DOI
関連識別子 info:doi/10.1038/ncomms7780
権利
権利情報 Copyright © 2015, Rights Managed by Nature Publishing Group
著者版フラグ
値 author
出版者
出版者 Nature Publishing Group
関係URI
識別子タイプ URI
関連識別子 http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/novel-regulatory-mechanisms-of-animal-growth-and-cell-proliferation.html
関係URI
識別子タイプ URI
関連識別子 http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/novel-regulatory-mechanisms-of-animal-growth-and-cell-proliferation.html
関係URI
識別子タイプ URI
関連識別子 http://www.nature.com/ncomms/2015/150416/ncomms7780/abs/ncomms7780.html
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