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Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity
http://hdl.handle.net/2261/58609
http://hdl.handle.net/2261/58609994ae7cb-1e5a-4612-975c-2dacd4ade20d
| 名前 / ファイル | ライセンス | アクション |
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ncomms7780_author_version.pdf (3.1 MB)
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ncomms7780_supplementary_author_version.pdf (2.7 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2015-10-20 | |||||
| タイトル | ||||||
| タイトル | Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Biological sciences | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Cell biology | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | journal article | |||||
| 著者 |
Fukushima, Toshiaki
× Fukushima, Toshiaki× Yoshihara, Hidehito× Furuta, Haruka× Kamei, Hiroyasu× Hakuno, Fumihiko× Luan, Jing× Duan, Cunming× Saeki, Yasushi× Tanaka, Keiji× Iemura, Shun-Ichiro× Natsume, Tohru× Chida, Kazuhiro× Nakatsu, Yusuke× Kamata, Hideaki× Asano, Tomoichiro× Takahashi, Shin-Ichiro |
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| 著者所属 | ||||||
| 著者所属 | Departments of Animal Sciences and Applied Biological Chemistry, Graduate School of Agriculture and Life Sciences, The University of Tokyo | |||||
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| 著者所属 | Department of Medical Science, Graduate School of Medicine, Hiroshima University | |||||
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| 著者所属 | Laboratory of Protein Metabolism, Tokyo Metropolitan Institute of Medical Science | |||||
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| 著者所属 | Key Laboratory of Marine Drugs, Chinese Ministry of Education, Ocean University of China | |||||
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| 著者所属 | Department of Molecular, Cellular and Developmental Biology, University of Michigan | |||||
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| 著者所属 | Molecular Profiling Research Center for Drug Discovery (molprof), National Institute of Advanced Industrial Science and Technology (AIST) | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Insulin-like growth factors (IGFs) induce proliferation of various cell types and play important roles in somatic growth and cancer development. Phosphorylation of insulin receptor substrate (IRS)-1/2 by IGF-I receptor tyrosine kinase is essential for IGF action. Here we identify Nedd4 as an IRS-2 ubiquitin ligase. Nedd4 monoubiquitinates IRS-2, which promotes its association with Epsin1, a ubiquitin-binding protein. Nedd4 recruits IRS-2 to the membrane, probably through promoting Epsin1 binding, and enhances IGF-I receptor-induced IRS-2 tyrosine phosphorylation. In thyroid FRTL-5 cells, activation of the cyclic AMP pathway increases the association of Nedd4 with IRS-2, thereby enhancing IRS-2-mediated signalling and cell proliferation induced by IGF-I. The Nedd4 and IRS-2 association is also required for maximal activation of IGF-I signalling and cell proliferation in prostate cancer PC-3 cells. Nedd4 overexpression accelerates zebrafish embryonic growth through IRS-2 in vivo. We conclude that Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity. | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | UTokyo Research掲載「動物の成長や細胞の増殖の新しい調節機構を発見」 URI: http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/novel-regulatory-mechanisms-of-animal-growth-and-cell-proliferation.html | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | UTokyo Research "Novel regulatory mechanisms of animal growth and cell proliferation" URI: http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/novel-regulatory-mechanisms-of-animal-growth-and-cell-proliferation.html | |||||
| 書誌情報 |
Nature communications 巻 6, p. 6780, 発行日 2015-04-15 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 20411723 | |||||
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| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA12645905 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | info:doi/10.1038/ncomms7780 | |||||
| 権利 | ||||||
| 権利情報 | Copyright © 2015, Rights Managed by Nature Publishing Group | |||||
| 著者版フラグ | ||||||
| 値 | author | |||||
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| 出版者 | Nature Publishing Group | |||||
| 関係URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/novel-regulatory-mechanisms-of-animal-growth-and-cell-proliferation.html | |||||
| 関係URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/novel-regulatory-mechanisms-of-animal-growth-and-cell-proliferation.html | |||||
| 関係URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.nature.com/ncomms/2015/150416/ncomms7780/abs/ncomms7780.html | |||||
