{"_buckets": {"deposit": "f3ce62af-0bed-4bd1-aa47-50474319ee7c"}, "_deposit": {"id": "710", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "710"}, "status": "published"}, "_oai": {"id": "oai:repository.dl.itc.u-tokyo.ac.jp:00000710"}, "item_2_biblio_info_7": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2015-04-15", "bibliographicIssueDateType": "Issued"}, "bibliographicPageStart": "6780", "bibliographicVolumeNumber": "6", "bibliographic_titles": [{"bibliographic_title": "Nature communications"}]}]}, "item_2_description_5": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Insulin-like growth factors (IGFs) induce proliferation of various cell types and play important roles in somatic growth and cancer development. Phosphorylation of insulin receptor substrate (IRS)-1/2 by IGF-I receptor tyrosine kinase is essential for IGF action. Here we identify Nedd4 as an IRS-2 ubiquitin ligase. Nedd4 monoubiquitinates IRS-2, which promotes its association with Epsin1, a ubiquitin-binding protein. Nedd4 recruits IRS-2 to the membrane, probably through promoting Epsin1 binding, and enhances IGF-I receptor-induced IRS-2 tyrosine phosphorylation. In thyroid FRTL-5 cells, activation of the cyclic AMP pathway increases the association of Nedd4 with IRS-2, thereby enhancing IRS-2-mediated signalling and cell proliferation induced by IGF-I. The Nedd4 and IRS-2 association is also required for maximal activation of IGF-I signalling and cell proliferation in prostate cancer PC-3 cells. Nedd4 overexpression accelerates zebrafish embryonic growth through IRS-2 in vivo. We conclude that Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity.", "subitem_description_type": "Abstract"}]}, "item_2_description_6": {"attribute_name": "\u5185\u5bb9\u8a18\u8ff0", "attribute_value_mlt": [{"subitem_description": "UTokyo Research\u63b2\u8f09\u300c\u52d5\u7269\u306e\u6210\u9577\u3084\u7d30\u80de\u306e\u5897\u6b96\u306e\u65b0\u3057\u3044\u8abf\u7bc0\u6a5f\u69cb\u3092\u767a\u898b\u300d URI: http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/novel-regulatory-mechanisms-of-animal-growth-and-cell-proliferation.html", "subitem_description_type": "Other"}, {"subitem_description": "UTokyo Research \"Novel regulatory mechanisms of animal growth and cell proliferation\" URI: http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/novel-regulatory-mechanisms-of-animal-growth-and-cell-proliferation.html", "subitem_description_type": "Other"}]}, "item_2_publisher_20": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Nature Publishing Group"}]}, "item_2_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "info:doi/10.1038/ncomms7780", "subitem_relation_type_select": "DOI"}}]}, "item_2_relation_25": {"attribute_name": "\u95a2\u4fc2URI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/novel-regulatory-mechanisms-of-animal-growth-and-cell-proliferation.html", "subitem_relation_type_select": "URI"}}, {"subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/novel-regulatory-mechanisms-of-animal-growth-and-cell-proliferation.html", "subitem_relation_type_select": "URI"}}, {"subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.nature.com/ncomms/2015/150416/ncomms7780/abs/ncomms7780.html", "subitem_relation_type_select": "URI"}}]}, "item_2_rights_12": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "Copyright \u00a9 2015, Rights Managed by Nature Publishing Group"}]}, "item_2_select_14": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_2_source_id_10": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA12645905", "subitem_source_identifier_type": "NCID"}]}, "item_2_source_id_8": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "20411723", "subitem_source_identifier_type": "ISSN"}]}, "item_2_text_34": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"subitem_text_value": "Jounal Article"}]}, "item_2_text_4": {"attribute_name": "\u8457\u8005\u6240\u5c5e", "attribute_value_mlt": [{"subitem_text_value": "Departments of Animal Sciences and Applied Biological Chemistry, Graduate School of Agriculture and Life Sciences, The University of Tokyo"}, {"subitem_text_value": "Department of Medical Science, Graduate School of Medicine, Hiroshima University"}, {"subitem_text_value": "Laboratory of Protein Metabolism, Tokyo Metropolitan Institute of Medical Science"}, {"subitem_text_value": "Key Laboratory of Marine Drugs, Chinese Ministry of Education, Ocean University of China"}, {"subitem_text_value": "Department of Molecular, Cellular and Developmental Biology, University of Michigan"}, {"subitem_text_value": "Molecular Profiling Research Center for Drug Discovery (molprof), National Institute of Advanced Industrial Science and Technology (AIST)"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Fukushima, Toshiaki"}], "nameIdentifiers": [{"nameIdentifier": "2635", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yoshihara, Hidehito"}], "nameIdentifiers": [{"nameIdentifier": "2636", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Furuta, Haruka"}], "nameIdentifiers": [{"nameIdentifier": "2637", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kamei, Hiroyasu"}], "nameIdentifiers": [{"nameIdentifier": "2638", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hakuno, Fumihiko"}], "nameIdentifiers": [{"nameIdentifier": "2639", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Luan, Jing"}], "nameIdentifiers": [{"nameIdentifier": "2640", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Duan, Cunming"}], "nameIdentifiers": [{"nameIdentifier": "2641", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Saeki, Yasushi"}], "nameIdentifiers": [{"nameIdentifier": "2642", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tanaka, Keiji"}], "nameIdentifiers": [{"nameIdentifier": "2643", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Iemura, Shun-Ichiro"}], "nameIdentifiers": [{"nameIdentifier": "2644", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Natsume, Tohru"}], "nameIdentifiers": [{"nameIdentifier": "2645", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Chida, Kazuhiro"}], "nameIdentifiers": [{"nameIdentifier": "2646", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakatsu, Yusuke"}], "nameIdentifiers": [{"nameIdentifier": "2647", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kamata, Hideaki"}], "nameIdentifiers": [{"nameIdentifier": "2648", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Asano, Tomoichiro"}], "nameIdentifiers": [{"nameIdentifier": "2649", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takahashi, Shin-Ichiro"}], "nameIdentifiers": [{"nameIdentifier": "2650", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-05-30"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "ncomms7780_author_version.pdf", "filesize": [{"value": "3.1 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 3100000.0, "url": {"label": "ncomms7780_author_version.pdf", "url": "https://repository.dl.itc.u-tokyo.ac.jp/record/710/files/ncomms7780_author_version.pdf"}, "version_id": "0859939b-4065-4403-8a0e-0e116cf9b791"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-05-30"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "ncomms7780_supplementary_author_version.pdf", "filesize": [{"value": "2.7 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 2700000.0, "url": {"label": "ncomms7780_supplementary_author_version.pdf", "url": "https://repository.dl.itc.u-tokyo.ac.jp/record/710/files/ncomms7780_supplementary_author_version.pdf"}, "version_id": "77cac4cb-157e-4b7b-ba1e-2e9a7c1a9034"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "Biological sciences", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Cell biology", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity"}]}, "item_type_id": "2", "owner": "1", "path": ["9/10/11", "27/183/184"], "permalink_uri": "http://hdl.handle.net/2261/58609", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_name_i18n": "\u516c\u958b\u65e5", "attribute_value": "2015-10-20"}, "publish_date": "2015-10-20", "publish_status": "0", "recid": "710", "relation": {}, "relation_version_is_last": true, "title": ["Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity"], "weko_shared_id": 2}