{"_buckets": {"deposit": "f3ce62af-0bed-4bd1-aa47-50474319ee7c"}, "_deposit": {"id": "710", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "710"}, "status": "published"}, "_oai": {"id": "oai:repository.dl.itc.u-tokyo.ac.jp:00000710"}, "item_2_biblio_info_7": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2015-04-15", "bibliographicIssueDateType": "Issued"}, "bibliographicPageStart": "6780", "bibliographicVolumeNumber": "6", "bibliographic_titles": [{"bibliographic_title": "Nature communications"}]}]}, "item_2_description_5": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Insulin-like growth factors (IGFs) induce proliferation of various cell types and play important roles in somatic growth and cancer development. Phosphorylation of insulin receptor substrate (IRS)-1/2 by IGF-I receptor tyrosine kinase is essential for IGF action. Here we identify Nedd4 as an IRS-2 ubiquitin ligase. Nedd4 monoubiquitinates IRS-2, which promotes its association with Epsin1, a ubiquitin-binding protein. Nedd4 recruits IRS-2 to the membrane, probably through promoting Epsin1 binding, and enhances IGF-I receptor-induced IRS-2 tyrosine phosphorylation. In thyroid FRTL-5 cells, activation of the cyclic AMP pathway increases the association of Nedd4 with IRS-2, thereby enhancing IRS-2-mediated signalling and cell proliferation induced by IGF-I. The Nedd4 and IRS-2 association is also required for maximal activation of IGF-I signalling and cell proliferation in prostate cancer PC-3 cells. Nedd4 overexpression accelerates zebrafish embryonic growth through IRS-2 in vivo. We conclude that Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity.", "subitem_description_type": "Abstract"}]}, "item_2_description_6": {"attribute_name": "\u5185\u5bb9\u8a18\u8ff0", "attribute_value_mlt": [{"subitem_description": "UTokyo Research\u63b2\u8f09\u300c\u52d5\u7269\u306e\u6210\u9577\u3084\u7d30\u80de\u306e\u5897\u6b96\u306e\u65b0\u3057\u3044\u8abf\u7bc0\u6a5f\u69cb\u3092\u767a\u898b\u300d URI: http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/novel-regulatory-mechanisms-of-animal-growth-and-cell-proliferation.html", "subitem_description_type": "Other"}, {"subitem_description": "UTokyo Research \"Novel regulatory mechanisms of animal growth and cell proliferation\" URI: http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/novel-regulatory-mechanisms-of-animal-growth-and-cell-proliferation.html", "subitem_description_type": "Other"}]}, "item_2_publisher_20": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": 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Graduate School of Agriculture and Life Sciences, The University of Tokyo"}, {"subitem_text_value": "Department of Medical Science, Graduate School of Medicine, Hiroshima University"}, {"subitem_text_value": "Laboratory of Protein Metabolism, Tokyo Metropolitan Institute of Medical Science"}, {"subitem_text_value": "Key Laboratory of Marine Drugs, Chinese Ministry of Education, Ocean University of China"}, {"subitem_text_value": "Department of Molecular, Cellular and Developmental Biology, University of Michigan"}, {"subitem_text_value": "Molecular Profiling Research Center for Drug Discovery (molprof), National Institute of Advanced Industrial Science and Technology (AIST)"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Fukushima, Toshiaki"}], "nameIdentifiers": [{"nameIdentifier": "2635", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yoshihara, Hidehito"}], 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