{"_buckets": {"deposit": "6ff3986f-4b34-4d6d-9c85-10c3e756b78e"}, "_deposit": {"id": "730", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "730"}, "status": "published"}, "_oai": {"id": "oai:repository.dl.itc.u-tokyo.ac.jp:00000730"}, "item_2_biblio_info_7": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2015-09-25", "bibliographicIssueDateType": "Issued"}, "bibliographicPageStart": "8219", "bibliographicVolumeNumber": "6", "bibliographic_titles": [{"bibliographic_title": "Nature communications"}]}]}, "item_2_description_5": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Modulation of epigenetic patterns has promising efficacy for treating cancer. 5-Hydroxymethylated cytosine (5-hmC) is an epigenetic mark potentially important in cancer. Here we report that 5-hmC is an epigenetic hallmark of prostate cancer (PCa) progression. A member of the ten\u2013eleven translocation (TET) proteins, which catalyse the oxidation of methylated cytosine (5-mC) to 5-hmC, TET2, is repressed by androgens in PCa. Androgen receptor (AR)-mediated induction of the miR-29 family, which targets TET2, are markedly enhanced in hormone refractory PCa (HRPC) and its high expression predicts poor outcome of PCa patients. Furthermore, decreased expression of miR-29b results in reduced tumour growth and increased TET2 expression in an animal model of HRPC. Interestingly, global 5-hmC modification regulated by miR-29b represses FOXA1 activity. A reduction in 5-hmC activates PCa-related key pathways such as mTOR and AR. Thus, DNA modification directly links the TET2-dependent epigenetic pathway regulated by AR to 5-hmC-mediated tumour progression.", "subitem_description_type": "Abstract"}]}, "item_2_description_6": {"attribute_name": "\u5185\u5bb9\u8a18\u8ff0", "attribute_value_mlt": [{"subitem_description": "UTokyo Research\u63b2\u8f09\u300c\u524d\u7acb\u817a\u764c\u306b\u5bfe\u3057\u3066\u30db\u30eb\u30e2\u30f3\u7642\u6cd5\u304c\u52b9\u304d\u3065\u3089\u304f\u306a\u308b\u7406\u7531\u300d URI: http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/why-hormone-therapy-becomes-ineffective-against-prostate-cancer.html", "subitem_description_type": "Other"}, {"subitem_description": "UTokyo Research \"Why hormone therapy becomes ineffective against prostate cancer\" URI: http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/why-hormone-therapy-becomes-ineffective-against-prostate-cancer.html", "subitem_description_type": "Other"}]}, "item_2_publisher_20": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Nature Publishing Group"}]}, "item_2_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "info:doi/10.1038/ncomms9219", "subitem_relation_type_select": "DOI"}}]}, "item_2_relation_25": {"attribute_name": "\u95a2\u4fc2URI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/why-hormone-therapy-becomes-ineffective-against-prostate-cancer.html", "subitem_relation_type_select": "URI"}}, {"subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/why-hormone-therapy-becomes-ineffective-against-prostate-cancer.html", "subitem_relation_type_select": "URI"}}, {"subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.nature.com/ncomms/2015/150925/ncomms9219/abs/ncomms9219.html", "subitem_relation_type_select": "URI"}}]}, "item_2_rights_12": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "Copyright \u00a9 2015, Rights Managed by Nature Publishing Group"}]}, "item_2_select_14": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_2_source_id_10": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA12645905", "subitem_source_identifier_type": "NCID"}]}, "item_2_source_id_8": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "20411723", "subitem_source_identifier_type": "ISSN"}]}, "item_2_text_34": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"subitem_text_value": "Jounal Article"}]}, "item_2_text_4": {"attribute_name": "\u8457\u8005\u6240\u5c5e", "attribute_value_mlt": [{"subitem_text_value": "Department of Anti-Aging Medicine, Graduate School of Medicine, The University of Tokyo"}, {"subitem_text_value": "Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo"}, {"subitem_text_value": "Department of Pathology, Graduate School of Medicine, Tohoku University"}, {"subitem_text_value": "RIKEN Omics Science Center (OSC), RIKEN Yokohama Institute"}, {"subitem_text_value": "RIKEN Preventive Medicine \u0026 Diagnosis Innovation Program"}, {"subitem_text_value": "Department of Urology, Graduate School of Medicine, The University of Tokyo"}, {"subitem_text_value": "Department of Urology, Nihon University School of Medicine"}, {"subitem_text_value": "Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical University"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Takayama, Ken-ichi"}], "nameIdentifiers": [{"nameIdentifier": "2743", 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