ログイン
言語:

WEKO3

  • トップ
  • コミュニティ
  • ランキング
AND
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

{"_buckets": {"deposit": "6ff3986f-4b34-4d6d-9c85-10c3e756b78e"}, "_deposit": {"id": "730", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "730"}, "status": "published"}, "_oai": {"id": "oai:repository.dl.itc.u-tokyo.ac.jp:00000730"}, "item_2_biblio_info_7": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2015-09-25", "bibliographicIssueDateType": "Issued"}, "bibliographicPageStart": "8219", "bibliographicVolumeNumber": "6", "bibliographic_titles": [{"bibliographic_title": "Nature communications"}]}]}, "item_2_description_5": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Modulation of epigenetic patterns has promising efficacy for treating cancer. 5-Hydroxymethylated cytosine (5-hmC) is an epigenetic mark potentially important in cancer. Here we report that 5-hmC is an epigenetic hallmark of prostate cancer (PCa) progression. A member of the ten\u2013eleven translocation (TET) proteins, which catalyse the oxidation of methylated cytosine (5-mC) to 5-hmC, TET2, is repressed by androgens in PCa. Androgen receptor (AR)-mediated induction of the miR-29 family, which targets TET2, are markedly enhanced in hormone refractory PCa (HRPC) and its high expression predicts poor outcome of PCa patients. Furthermore, decreased expression of miR-29b results in reduced tumour growth and increased TET2 expression in an animal model of HRPC. Interestingly, global 5-hmC modification regulated by miR-29b represses FOXA1 activity. A reduction in 5-hmC activates PCa-related key pathways such as mTOR and AR. Thus, DNA modification directly links the TET2-dependent epigenetic pathway regulated by AR to 5-hmC-mediated tumour progression.", "subitem_description_type": "Abstract"}]}, "item_2_description_6": {"attribute_name": "\u5185\u5bb9\u8a18\u8ff0", "attribute_value_mlt": [{"subitem_description": "UTokyo Research\u63b2\u8f09\u300c\u524d\u7acb\u817a\u764c\u306b\u5bfe\u3057\u3066\u30db\u30eb\u30e2\u30f3\u7642\u6cd5\u304c\u52b9\u304d\u3065\u3089\u304f\u306a\u308b\u7406\u7531\u300d URI: http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/why-hormone-therapy-becomes-ineffective-against-prostate-cancer.html", "subitem_description_type": "Other"}, {"subitem_description": "UTokyo Research \"Why hormone therapy becomes ineffective against prostate cancer\" URI: http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/why-hormone-therapy-becomes-ineffective-against-prostate-cancer.html", "subitem_description_type": "Other"}]}, "item_2_publisher_20": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Nature Publishing Group"}]}, "item_2_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "info:doi/10.1038/ncomms9219", "subitem_relation_type_select": "DOI"}}]}, "item_2_relation_25": {"attribute_name": "\u95a2\u4fc2URI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/why-hormone-therapy-becomes-ineffective-against-prostate-cancer.html", "subitem_relation_type_select": "URI"}}, {"subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/why-hormone-therapy-becomes-ineffective-against-prostate-cancer.html", "subitem_relation_type_select": "URI"}}, {"subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.nature.com/ncomms/2015/150925/ncomms9219/abs/ncomms9219.html", "subitem_relation_type_select": "URI"}}]}, "item_2_rights_12": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "Copyright \u00a9 2015, Rights Managed by Nature Publishing Group"}]}, "item_2_select_14": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_2_source_id_10": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA12645905", "subitem_source_identifier_type": "NCID"}]}, "item_2_source_id_8": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "20411723", "subitem_source_identifier_type": "ISSN"}]}, "item_2_text_34": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"subitem_text_value": "Jounal Article"}]}, "item_2_text_4": {"attribute_name": "\u8457\u8005\u6240\u5c5e", "attribute_value_mlt": [{"subitem_text_value": "Department of Anti-Aging Medicine, Graduate School of Medicine, The University of Tokyo"}, {"subitem_text_value": "Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo"}, {"subitem_text_value": "Department of Pathology, Graduate School of Medicine, Tohoku University"}, {"subitem_text_value": "RIKEN Omics Science Center (OSC), RIKEN Yokohama Institute"}, {"subitem_text_value": "RIKEN Preventive Medicine \u0026 Diagnosis Innovation Program"}, {"subitem_text_value": "Department of Urology, Graduate School of Medicine, The University of Tokyo"}, {"subitem_text_value": "Department of Urology, Nihon University School of Medicine"}, {"subitem_text_value": "Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical University"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Takayama, Ken-ichi"}], "nameIdentifiers": [{"nameIdentifier": "2743", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Misawa, Aya"}], "nameIdentifiers": [{"nameIdentifier": "2744", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suzuki, Takashi"}], "nameIdentifiers": [{"nameIdentifier": "2745", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takagi, Kiyoshi"}], "nameIdentifiers": [{"nameIdentifier": "2746", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hayashizaki, Yoshihide"}], "nameIdentifiers": [{"nameIdentifier": "2747", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fujimura, Tetsuya"}], "nameIdentifiers": [{"nameIdentifier": "2748", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Homma, Yukio"}], "nameIdentifiers": [{"nameIdentifier": "2749", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takahashi, Satoru"}], "nameIdentifiers": [{"nameIdentifier": "2750", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Urano, Tomohiko"}], "nameIdentifiers": [{"nameIdentifier": "2751", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Inoue, Satoshi"}], "nameIdentifiers": [{"nameIdentifier": "2752", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-05-30"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "ncomms9219.pdf", "filesize": [{"value": "4.2 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 4200000.0, "url": {"label": "ncomms9219.pdf", "url": "https://repository.dl.itc.u-tokyo.ac.jp/record/730/files/ncomms9219.pdf"}, "version_id": "a5ed2add-4be9-417e-bfef-49d0e76015d5"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "Biological sciences", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Cancer", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "TET2 repression by androgen hormone regulates global hydroxymethylation status and prostate cancer progression", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "TET2 repression by androgen hormone regulates global hydroxymethylation status and prostate cancer progression"}]}, "item_type_id": "2", "owner": "1", "path": ["9/10/11", "125/199/200"], "permalink_uri": "http://hdl.handle.net/2261/59314", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2016-03-28"}, "publish_date": "2016-03-28", "publish_status": "0", "recid": "730", "relation": {}, "relation_version_is_last": true, "title": ["TET2 repression by androgen hormone regulates global hydroxymethylation status and prostate cancer progression"], "weko_shared_id": 2}
  1. 112 医学系研究科・医学部
  2. 82 22世紀医療センター
  3. 1128210 学術雑誌論文
  1. 0 資料タイプ別
  2. 10 学術雑誌論文
  3. 014 自然科学

TET2 repression by androgen hormone regulates global hydroxymethylation status and prostate cancer progression

http://hdl.handle.net/2261/59314
d828e9a1-7bd9-405e-8d73-c995f30c46c5
名前 / ファイル ライセンス アクション
ncomms9219.pdf ncomms9219.pdf (4.2 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2016-03-28
タイトル
タイトル TET2 repression by androgen hormone regulates global hydroxymethylation status and prostate cancer progression
言語
言語 eng
キーワード
主題 Biological sciences
主題Scheme Other
キーワード
主題 Cancer
主題Scheme Other
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Takayama, Ken-ichi

× Takayama, Ken-ichi

WEKO 2743

Takayama, Ken-ichi

Search repository
Misawa, Aya

× Misawa, Aya

WEKO 2744

Misawa, Aya

Search repository
Suzuki, Takashi

× Suzuki, Takashi

WEKO 2745

Suzuki, Takashi

Search repository
Takagi, Kiyoshi

× Takagi, Kiyoshi

WEKO 2746

Takagi, Kiyoshi

Search repository
Hayashizaki, Yoshihide

× Hayashizaki, Yoshihide

WEKO 2747

Hayashizaki, Yoshihide

Search repository
Fujimura, Tetsuya

× Fujimura, Tetsuya

WEKO 2748

Fujimura, Tetsuya

Search repository
Homma, Yukio

× Homma, Yukio

WEKO 2749

Homma, Yukio

Search repository
Takahashi, Satoru

× Takahashi, Satoru

WEKO 2750

Takahashi, Satoru

Search repository
Urano, Tomohiko

× Urano, Tomohiko

WEKO 2751

Urano, Tomohiko

Search repository
Inoue, Satoshi

× Inoue, Satoshi

WEKO 2752

Inoue, Satoshi

Search repository
著者所属
著者所属 Department of Anti-Aging Medicine, Graduate School of Medicine, The University of Tokyo
著者所属
著者所属 Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo
著者所属
著者所属 Department of Pathology, Graduate School of Medicine, Tohoku University
著者所属
著者所属 RIKEN Omics Science Center (OSC), RIKEN Yokohama Institute
著者所属
著者所属 RIKEN Preventive Medicine & Diagnosis Innovation Program
著者所属
著者所属 Department of Urology, Graduate School of Medicine, The University of Tokyo
著者所属
著者所属 Department of Urology, Nihon University School of Medicine
著者所属
著者所属 Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical University
抄録
内容記述タイプ Abstract
内容記述 Modulation of epigenetic patterns has promising efficacy for treating cancer. 5-Hydroxymethylated cytosine (5-hmC) is an epigenetic mark potentially important in cancer. Here we report that 5-hmC is an epigenetic hallmark of prostate cancer (PCa) progression. A member of the ten–eleven translocation (TET) proteins, which catalyse the oxidation of methylated cytosine (5-mC) to 5-hmC, TET2, is repressed by androgens in PCa. Androgen receptor (AR)-mediated induction of the miR-29 family, which targets TET2, are markedly enhanced in hormone refractory PCa (HRPC) and its high expression predicts poor outcome of PCa patients. Furthermore, decreased expression of miR-29b results in reduced tumour growth and increased TET2 expression in an animal model of HRPC. Interestingly, global 5-hmC modification regulated by miR-29b represses FOXA1 activity. A reduction in 5-hmC activates PCa-related key pathways such as mTOR and AR. Thus, DNA modification directly links the TET2-dependent epigenetic pathway regulated by AR to 5-hmC-mediated tumour progression.
内容記述
内容記述タイプ Other
内容記述 UTokyo Research掲載「前立腺癌に対してホルモン療法が効きづらくなる理由」 URI: http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/why-hormone-therapy-becomes-ineffective-against-prostate-cancer.html
内容記述
内容記述タイプ Other
内容記述 UTokyo Research "Why hormone therapy becomes ineffective against prostate cancer" URI: http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/why-hormone-therapy-becomes-ineffective-against-prostate-cancer.html
書誌情報 Nature communications

巻 6, p. 8219, 発行日 2015-09-25
ISSN
収録物識別子タイプ ISSN
収録物識別子 20411723
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA12645905
DOI
関連識別子
識別子タイプ DOI
関連識別子 info:doi/10.1038/ncomms9219
権利
権利情報 Copyright © 2015, Rights Managed by Nature Publishing Group
著者版フラグ
値 author
出版者
出版者 Nature Publishing Group
関係URI
関連識別子
識別子タイプ URI
関連識別子 http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/why-hormone-therapy-becomes-ineffective-against-prostate-cancer.html
関係URI
関連識別子
識別子タイプ URI
関連識別子 http://www.u-tokyo.ac.jp/en/utokyo-research/research-news/why-hormone-therapy-becomes-ineffective-against-prostate-cancer.html
関係URI
関連識別子
識別子タイプ URI
関連識別子 http://www.nature.com/ncomms/2015/150925/ncomms9219/abs/ncomms9219.html
戻る
0
views
See details
Views

Versions

Ver.1 2021-03-01 16:39:42.975047
Show All versions

Share

Mendeley CiteULike Twitter Facebook Print Addthis

Cite as

Export

OAI-PMH
  • OAI-PMH JPCOAR
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by CERN Data Centre & Invenio


Powered by CERN Data Centre & Invenio