{"_buckets": {"deposit": "42169676-9d99-49f3-9b56-7243c33e4b25"}, "_deposit": {"id": "36", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "36"}, "status": "published"}, "_oai": {"id": "oai:repository.dl.itc.u-tokyo.ac.jp:00000036"}, "item_2_biblio_info_7": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2003-06-20", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "12", "bibliographicPageEnd": "1636", "bibliographicPageStart": "1631", "bibliographicVolumeNumber": "14", "bibliographic_titles": [{"bibliographic_title": "Tetrahedron, asymmetry"}]}]}, "item_2_description_13": {"attribute_name": "\u30d5\u30a9\u30fc\u30de\u30c3\u30c8", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_2_description_5": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "The resolution of racemic 3-(methylamino)-1-(2-thienyl)propan-1-ol (3), a new key intermediate for duloxetine (1), was studied.  The conditions were optimized for an industrial-scale resolution of 3 by using (S)-mandelic acid (4) as a resolving agent and 2-butanol containing two equimolar amounts of water as a solvent.  The (S)-3\uff65(S)-4\uff65H2O diastereomeric salt was crystallized to give pure (S)-3 with \u003e99.9% ee after liberation of the amine.  Absolute configuration of liberated (-)-3 was determined as (S)-form by X-ray crystallography.", "subitem_description_type": "Abstract"}]}, "item_2_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "155", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "\u897f\u90f7, \u548c\u5f66"}]}]}, "item_2_publisher_20": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Elsevier"}]}, "item_2_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "info:doi/10.1016/S0957-4166(03)00315-X", "subitem_relation_type_select": "DOI"}}]}, "item_2_relation_25": {"attribute_name": "\u95a2\u4fc2URI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.sciencedirect.com/science/journal/09574166", "subitem_relation_type_select": "URI"}}]}, "item_2_select_14": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_2_source_id_10": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA1074621X", "subitem_source_identifier_type": "NCID"}]}, "item_2_source_id_8": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "09574166", "subitem_source_identifier_type": "ISSN"}]}, "item_2_text_34": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"subitem_text_value": "Journal Article"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Saigo, Kazuhiko"}], "nameIdentifiers": [{"nameIdentifier": "150", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sakai, Kenichi"}], "nameIdentifiers": [{"nameIdentifier": "151", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sakurai, Rumiko"}], "nameIdentifiers": [{"nameIdentifier": "152", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yuzawa, Atsushi"}], "nameIdentifiers": [{"nameIdentifier": "153", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kobayashi, Yuka"}], "nameIdentifiers": [{"nameIdentifier": "154", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-05-30"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "1_Elsevier.pdf", "filesize": [{"value": "106.7 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 106700.0, "url": {"label": "1_Elsevier.pdf", "url": "https://repository.dl.itc.u-tokyo.ac.jp/record/36/files/1_Elsevier.pdf"}, "version_id": "4f27b14f-9658-4e5f-97f6-6219cb2ebbba"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Resolution of 3-(methylamino)-1-(2-thienyl)propan-1-ol, a new key intermediate for duloxetine, with (S)-mandelic acid", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Resolution of 3-(methylamino)-1-(2-thienyl)propan-1-ol, a new key intermediate for duloxetine, with (S)-mandelic acid"}]}, "item_type_id": "2", "owner": "1", "path": ["9/10/11", "6/18/19"], "permalink_uri": "http://hdl.handle.net/2261/3990", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2007-01-10"}, "publish_date": "2007-01-10", "publish_status": "0", "recid": "36", "relation": {}, "relation_version_is_last": true, "title": ["Resolution of 3-(methylamino)-1-(2-thienyl)propan-1-ol, a new key intermediate for duloxetine, with (S)-mandelic acid"], "weko_shared_id": null}